I found this article very poignant, and it really resonated with me that often start up business owners have to motivate themselves each and every day, they don't have anyone else to share the burden or to tell them to go home and get some rest. You deal with the highs the lows and the sleepless nights all on your own. No wonder there is a high instance of depression. Make sure you are getting the right sort of support before it happens, you need to make sure you take care of yourself.